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Drugs for Treatment of Premature Ejaculation

By , About.com Guide

Updated July 02, 2009

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A number of studies have found that selective serotonin reuptake inhibitors (SSRIs) which are commonly used to treat depression, have the side effect of delaying ejaculation. It seems as if off label prescribing of SSRIs for premature ejaculation may be a common occurrence. This should be a cause for concern, given that SSRIs come with a variety of side effects, including other forms of sexual dysfunction. Studies have looked at paroxetine, fluoxetine, and sertraline, among others.

Another group of drug products that are used to treat premature ejaculation are the desensitizing creams and sprays that contain local anesthetics (most often benzocaine). Available in both drugstores and retail sex stores, these products simply numb the skin, which ensures a man will maintain an erection longer by eliminating most of his sexual pleasure. In clinical studies these desensitizing creams have been found effective in delaying ejaculation.

But choosing to forgo sexual sensitivity and pleasure in the name of “lasting longer” is a sad choice for men to have to make. These products come with other drawbacks, usually related to problems in use. If applied too early, the decreased sensation may make it difficult for a man to get an erection. If applied too late, and not allowed to absorb in the skin, the product can rub off on a sexual partner and desensitize their genital area as well.

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Sources:

  1. The Lancet 2006; 368:929-937. “Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials.”
  2. Off-label SSRI use for premature ejaculation gains momentum. Richard White, National Review of Medicine, November 15, 2004.
  3. Topical anesthetic use for treating premature ejaculation. W. Busato & C.C. Galindo, British Journal of Urology, Vol. 93, May 2004.
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